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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Antonio Higuera# | 464 | 2007-2025 | |
| 2 | Corey Gruver# | 358 | 2006-2025 | |
| 3 | Eric Burdine* | 333 | 2000-2017 | |
| 3 | Geremia Farinelli | 333 | 2000-2014 | |
| 5 | Heriberto Milan | 319 | 2007-2022 | |
| 5 | Greg Sandlin# | 319 | 2009-2024 | |
| 7 | Jordan Clarke | 314 | 2004-2023 | |
| 8 | Barry McLamb# | 309 | 2013-2023 | |
| 8 | J.R. Mitchell# | 309 | 2013-2025 | |
| 10 | Chad Landreth | 306 | 2001-2017 | |
| 11 | Jonathan Luna | 287 | 2000-2011 | |
| 12 | David Nations | 283 | 2000-2008 | |
| 13 | Vance Adams | 281 | 2000-2013 | |
| 14 | Xiang-ling Fei* | 273 | 2000-2012 | |
| 15 | Tony Lopez | 265 | 2013-2021 | |
| 16 | William Arredondo | 263 | 2000-2012 | |
| 16 | Albert Fabian# | 263 | 2014-2025 | |
| 18 | Miles Hale | 261 | 2000-2011 | |
| 19 | Kyle Ziegler | 259 | 2000-2011 | |
| 20 | Carlos Mendez# | 258 | 2011-2025 | |
| 21 | Jose Alvarado | 257 | 2006-2016 | |
| 22 | Alfredo Tiscareno# | 255 | 2010-2025 | |
| 23 | Brian Chambliss | 252 | 2000-2014 | |
| 24 | Casey Abbott# | 250 | 2009-2025 | |
| 24 | Chris McLure | 250 | 2000-2010 | |
| 26 | Jay Helm# | 249 | 2015-2025 | |
| 26 | John Way# | 249 | 2016-2025 | |
| 28 | Tyrone Hairston | 248 | 2002-2013 | |
| 29 | Brian Rohde | 239 | 2009-2020 | |
| 30 | Zachary Christman# | 237 | 2014-2025 | |
| 31 | Edwin Gutierrez | 235 | 2000-2010 | |
| 32 | Sean Bartol | 232 | 2000-2010 | |
| 33 | Paul Ledford* | 230 | 2000-2013 | |
| 34 | Brian Prince# | 229 | 2011-2024 | |
| 35 | Russ Allen | 228 | 2000-2012 | |
| 35 | Jose Moreno | 228 | 2000-2014 | |
| 37 | Du-sung Moon | 227 | 2002-2015 | |
| 38 | John Froerer# | 225 | 2015-2025 | |
| 39 | Gates Callaghan | 224 | 2004-2014 | |
| 40 | Tom Kitko | 223 | 2012-2023 | |
| 41 | Pat Gonzalez | 222 | 2000-2013 | |
| 41 | Andy Shoemaker# | 222 | 2012-2023 | |
| 43 | Tony Figueroa | 219 | 2014-2021 | |
| 44 | Bobby Dodd | 217 | 2005-2016 | |
| 44 | Nick Mathiesen | 217 | 2000-2010 | |
| 46 | Seth Carey | 216 | 2004-2016 | |
| 47 | Xavier Cooper# | 215 | 2014-2025 | |
| 48 | Winston Caballero# | 212 | 2015-2025 | |
| 48 | Iliana Preciado | 212 | 2000-2009 | |
| 50 | Hiromi Fukuda | 210 | 2006-2018 | |
| 50 | Jeremy Gray# | 210 | 2013-2025 | |
| 52 | Jon Haynes# | 209 | 2014-2025 | |
| 53 | Felipe Ayala# | 207 | 2013-2025 | |
| 53 | Cody Morosko | 207 | 2000-2010 | |
| 55 | Eric Angelone | 205 | 2004-2013 | |
| 56 | Hector Ruiz | 203 | 2001-2013 | |
| 56 | Bill Vasquez | 203 | 2000-2012 | |
| 58 | Jonathan Allen# | 201 | 2016-2025 | |
| 59 | Rodrigo Lemus# | 200 | 2013-2025 | |
| 60 | Nick Lawson | 199 | 2002-2017 | |
| 60 | Miguel Leon# | 199 | 2017-2025 | |
| 60 | Sergio Penichet# | 199 | 2013-2025 | |
| 63 | Octavio Ruiz | 198 | 2000-2011 | |
| 63 | Rodolfo Soto# | 198 | 2015-2025 | |
| 65 | Felipe Gonzalez | 197 | 2011-2020 | |
| 66 | Adrian Huffine# | 196 | 2015-2025 | |
| 66 | Andres Moran | 196 | 2011-2022 | |
| 68 | Tony Marcano | 195 | 2000-2011 | |
| 69 | Rogelio Aburto | 192 | 2009-2020 | |
| 69 | Dave Shevlin | 192 | 2013-2024 | |
| 71 | Andy Dooley# | 190 | 2014-2025 | |
| 72 | Jason Strobel# | 189 | 2014-2025 | |
| 73 | Tommy Bressette | 188 | 2000-2009 | |
| 73 | Lorenzo Villarreal# | 188 | 2014-2024 | |
| 75 | Jeremy Hewes | 187 | 2010-2022 | |
| 75 | Ryan Heyer# | 187 | 2017-2025 | |
| 77 | Chris Kuperman | 186 | 2002-2012 | |
| 77 | Jorge Lopez | 186 | 2004-2013 | |
| 79 | Josh Flaten# | 184 | 2015-2025 | |
| 80 | Seth Dann | 183 | 2002-2013 | |
| 80 | Ching Ding | 183 | 2000-2009 | |
| 80 | Noah George | 183 | 2005-2017 | |
| 80 | Jeff Glissman | 183 | 2000-2010 | |
| 84 | Pat Hovhannisian# | 180 | 2014-2025 | |
| 85 | Bill Flowers# | 179 | 2011-2025 | |
| 85 | Sukeaki Kato | 179 | 2001-2014 | |
| 87 | Chris Harris | 176 | 2007-2020 | |
| 88 | Johnny Keener# | 175 | 2015-2025 | |
| 88 | Julio Melendez | 175 | 2000-2012 | |
| 88 | Bill Rauch | 175 | 2011-2023 | |
| 91 | Alex Dopico | 172 | 2000-2009 | |
| 91 | Kory Tourville# | 172 | 2014-2024 | |
| 93 | Alex Alvarez | 171 | 2010-2019 | |
| 94 | Jeff Rochefort | 170 | 2009-2019 | |
| 94 | Kyle Rodriguez# | 170 | 2014-2023 | |
| 96 | Chris Benson# | 169 | 2017-2025 | |
| 96 | Jonathan Gonzales | 169 | 2012-2023 | |
| 96 | Yosaburo Kanda | 169 | 2013-2022 | |
| 96 | Travis Thurber# | 169 | 2005-2024 | |
| 96 | Tim Ward | 169 | 2000-2009 |
